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Anti-Wrinkle Advisor Text

 

Please check your age group:

bullet2.png17 - 29
bullet2.png30 - 39
bullet2.png40 - 60
bullet2.pngover 60

 

Skin Care products can be select by age, as well as by your personal skin care concerns, such as dry skin, photoaging, aging skin, wrinkles.

 

Beauty Classics  Anti-Aging Anti-Wrinkle Advisor 17 – 29

Please check on your skin care concern:

bullet2.pngDry Skin - Skin wrinkling mainly around eyes, where skin is thinner and drier than the rest of the face.
bullet2.pngPhotoaging - For younger individuals, surface facial wrinkles can be a sign excessive sun exposure.
bullet2.pngAging Skin - Skin looks smooth, but AGE formation and the cross-linking of skin proteins must be inhibited.

 

Early intervention is critical in inhibiting skin aging, because collagen and elastin cross-linking that cause wrinkles is irreversible if not prevented as soon as possible. Photoaging and dry skin contribute to the formation of surface skin wrinkles.

 

 

R

ecent research has revealed that skin aging is due to the nonenzymatic glycation of protein, in which the amino acids of protein are chemically modified by the attachment of glucose or other sugars, or ascorbic acid (vitamin C; ASA) or its oxidation products, L-threose and dehydroascorbic acid (DHA). The glycated amino acids in long-lived proteins, such as collagen and elastin, make them susceptible to cross-linking that causes skin to age.

bullet2.pngThe long-term exposure of collagen or elastin to even low glucose or ASA levels eventually results in a multi-step process, that involves the binding of glucose or ASA to protein and the subsequent formation of advanced glycosylation end-products (AGEs), which are highly active in the cross-linking of protein.

bullet2.pngProtein cross-linking is important, since it reduces skin elasticity, which leads to the stiffening of skin, and is responsible for the deep wrinkling in the dermis of the skin. AGEs also contribute to other visual signs of skin aging, such as yellowing skin and age spots.

bullet2.pngThe nonenzymatic glycation of collagen and elastin, and formation of AGEs are reversible reactions if caught early, but the cross-linking of proteins, that causes permanent wrinkles, is irreversible. Therefore, the cross-linking of AGE-modified collagen and elastin must be inhibited to impede the onset of wrinkles and skin aging.

bullet2.pngThe nonenzymatic glycation and cross-linking of collagen and elastin occurs early in life, as well as throughout a person’s lifetime. The level of AGEs in collagen are low up until about the age of 18 years old, and then rapidly increases after this age. This age-related increase in collagen AGE levels correlates with increased collagen cross-linking and skin wrinkling. Therefore, a preventative skin care treatment should be adopted as soon as possible, since protein cross-linking that forms wrinkles is irreversible.

Hence our Pharmacist Formulary Product

BEAUTY CLASSICS® Check1red.pngDermAge Anti-Wrinkle Inhibitor™

An Anti-Aging Inhibitor Face Moisturizer

bullet2.pngSkin aging results from the cross-linking of collagen and elastin, which causes skin stiffening that forms wrinkles and other signs of aging. A solution to the problem of preventing skin aging is to mimic the natural conditions in skin that inhibit cross-linking.

bullet2.png DermAge Anti-Wrinkle Inhibitor™ Face Moisturizer is the basis of BEAUTY CLASSICS®  exclusive preventative treatment for younger adults. It inhibits protein cross-linking that ages skin and naturally sustains the skin’s healthy, youthful appearance.

bullet2.pngThe DermAge’s active ingredients are natural constituents of human skin that inhibit skin aging.

bullet2.pngFor middle-aged adults, BEAUTY CLASSICS®Check1red.pngDermAge Anti-Wrinkle Sculpturer™ Face Moisturizer is recommended. Individuals in their thirties may benefit most by using  Check1red.pngDermAge Anti-Wrinkle Inhibitor™  Face Moisturizer as a day treatment with Check1red.pngDermAge Anti-Wrinkle Sculpturer™   Face Moisturizer as a night treatment.

bullet2.pngIn summary, collagen and elastin are subject to nonenzymatic glycation in which glucose or ascorbic acid chemically attaches to amino acids. Once collagen and elastin are glycated and forms AGEs, they have the potential to cross-link other protein molecules. Once cross-linked, the cross-linking is irreversible. Therefore, early intervention is critical in inhibiting protein cross-linking that forms wrinkles and ages skin.
 
  


 

BEAUTY CLASSICS® DermAge™ SkinCare and Alternative Usage Strategies

bullet2.png DermAge Anti-Wrinkle Inhibitor™ Face Moisturizer is recommended for those individuals who wish to inhibit further skin wrinkling. Younger adult are strongly encouraged to start using DermAge™ as a preventative strategy before the signs of aging are visible.

bullet2.pngFor middle-aged individuals,  DermAge Anti-Wrinkle Sculpturer™ Face Moisturizer may be a better skin care choice, since it diminishes the appearance of wrinkles, while having the same antiaging benefits as DermAge Anti-Wrinkle Inhibitor™ .

bullet2.png DermAge Anti-Wrinkle Inhibitor™  Face Moisturizer can be used in conjunction with other BEAUTY CLASSICS® Skin Care Products.

bullet2.pngFor those exposed to the sun,Check1red.png DermAge Anti-Wrinkle Inhibitor™ Face Moisturizer can be used as a night treatment with   Check1red.pngDermAge Anti-PhotoAging Defender™ Face Moisturizer used as a day treatment. Or Check1red.pngDermAge Anti-Wrinkle Inhibitor™ Face Moisturizer can be used together with Check1red.pngDermAge Anti-PhotoAging Defender™   Face Moisturizer to maximize the antiaging benefits of both products. Anti- Wrinkle Inhibitor  should be applied 10 minutes before Anti-PhotoAging is applied.

bullet2.pngAll DermAge™ Skin Care Products are fragrance-free and  DermAge Anti-Wrinkle Inhibitor™ Face Moisturizer should be applied evenly to clean, dry skin. A temporary tingling sensation may be felt, as  it revitalizes the skin. For sensitive skin, wait 15 minutes after cleansing face before applying.  It should be used twice daily, morning and evening. Besides inhibiting skin aging, an improvement in the appearance of the skin should also be seen with daily use.    

Face Moisturizer diminishes the appearance of wrinkles and inhibits the formation of new wrinkles. By rehabilitating skin, bullet1.pngDry Skin Fluid™, bullet1.pngDry Skin Cream™, bullet1.pngDermAge Anti-Wrinkle Inhibitor™, bullet1.pngDermAge Anti-Wrinkle Sculpturer™, bullet1.pngDermAge Anti-PhotoAging Defender™ and DermAge Moisture Invigorator™,  break the vicious cycle of protein cross-linking that accelerates skin aging.  

The Science Behind Check1red.pngDermAge Anti-Wrinkle Sculpturer™

bullet2.pngThe glycation or chemical attachment of glucose and ascorbic acid (vitamin C; ASA) to long-lived proteins, such as collagen and elastin can lead to the spontaneous formation of advanced glycosylation end-products (AGEs), which are highly reactive in cross-linking protein. Protein cross-linking is important, since it is an irreversible process that is responsible for the permanent, deep wrinkling in the dermis of the skin.

bullet2.pngOne of the sobering facts derived from the accumulated knowledge about the nonenzymatic glycation of protein is the ability of AGE-modified collagen to continue trapping and cross-linking unmodified protein, even in the absence of free glucose or ASA. This means that skin can continue to age once AGEs are formed on collagen.

bullet2.pngThe level of AGEs in collagen are low up until about the age of 18 years old, and then rapidly increases after this age. This is because there is extensively collagen remodelling occuring at younger ages, which quickly slows after maturity. The age-related increase in collagen AGE-levels correlates with accelerated skin aging and the formation of wrinkles.

bullet2.pngAlso, the values of serum AGEs for women beyond age 50 are significantly higher than for younger women. The AGE-values for women aged 80-93 is three-fold higher than women aged 20-29. There are higher AGE-values for older women, because AGE synthesis increases with age. The age-related increase in serum AGE-values correlates with accelerated skin aging and the formation of wrinkles.

bullet2.pngAlthough collagen turnover may be regulated independently from cross-linking, cross-linking itself can impair collagen turnover. This is because cross-linked collagen is less susceptible to natural corrective actions, such as collagenase digestion and macrophage-mediated degradation. Eventually, the extracellular matrix of the skin become so knotted by cross-linked collagen, that the natural balance is disturbed between the cross-linking of collagen and the mechanisms that correct collagen cross-linking.

bullet2.pngAs a result of this self-perpetuating component of glucose- and ASA-mediated tissue damage, a vicious cycle occurs in which cross-linking continues to happen with the natural remodeling process unable to correct it, further impairing collagen turnover and leading to an accelerated rate of skin aging, as seen in older people.

bullet2.pngA recent study showed that protein turnover is a major determinant in the accumulation of AGEs in skin collagen. AGEs were found to increase with age in both skin collagen and cartilage. However, AGE accumulation was higher in cartilage than in skin collagen indicating that cartilage has a slower turnover rate. Cartilage collagen was found to age more quickly than skin collagen, indicating that the remodeling of AGE-modified collagen inhibits skin aging.

BEAUTY CLASSICS® Check1red.pngDermAge Anti-Wrinkle Sculpturer™ Face Moisturizer

bullet2.pngDuring middle-age skin aging accelerates due to increased collagen cross-linking that suppresses collagen turnover. A solution to the problem of revitalizing aging skin is to mimic the natural conditions in skin that induce skin renewal.

bullet2.png Check1red.pngDermAge Anti-Wrinkle Sculpturer™ Face Moisturizer is the basis of DermAge™ exclusive rehabilitative treatment for mid-life adults. It diminishes the appearance of wrinkles and naturally revives the skin’s healthy, youthful appearance.

bullet2.png DermAge Anti-Wrinkle Sculpturer™ Face Moisturizer’s active ingredients are natural constituents of human skin that rehabilitate aging skin.

bullet2.pngFor younger adults, DermAge Wrinkle Inhibitor™ Face Moisturizer is recommended. Individuals in their thirties may benefit most by using DermAge Anti-Wrinkle Sculpturer™ Face Moisturizer as a night treatment with DermAge Anti-Wrinkle Inhibitor™ Face Moisturizer as a day treatment.

bullet2.pngIn summary, once collagen is glycated it has the potential to form AGEs and cross-link other protein molecules. Once proteins are cross-linked, the cross-linking is irreversible. Extensive glycation and cross-linking of collagen impedes the natural remodeling mechanisms that correct cross-linking, which eventually impairs collagen turnover. This situation results in a vicious cycle in which skin aging is accelerated.


bullet2.pngFor those with very dry skin, DermAge Anti-Wrinkle Sculpturer™ Face Moisturizer can be used as a night treatment, when the evaporation of skin moisture is less of a problem.

bullet2.pngFor those exposed to the sun, DermAge Anti-Wrinkle Sculpturer™ Face Moisturizer can be used as a night treatment with DermAge Anti-PhotoAging Defender™ Face Moisturizer used as a day treatment. Or DermAge Anti-Wrinkle Sculpturer™ Face Moisturizer can be used together with DermAge Anti-PhotoAging Defender™ Face Moisturizer to maximize the antiaging benefits of both products. Anti-Wrinkle Sculpturer™ should be applied 10 minutes before  Anti-PhotoAging Defender™ is applied.

 DermAge Anti-Wrinkle Sculpturer™ Face Moisturizer should be used twice daily, morning and evening. The appearance of wrinkles should be noticeably diminished after the use of just one bottle or sooner. A steady improvement in the appearance of the skin should be seen with continuous daily use.

 

BEAUTY CLASSICS™ Anti-Aging Anti-Wrinkle Advisor 40 - 60
       


Please check on your skin care concern:

bullet2.pngDry Skin - Skin wrinkling from dry skin is causing webbing around eyes and on face.
bullet2.pngPhotoaging - Surface and some deep skin wrinkles are signs that skin needs immediate attention.
bullet2.pngWrinkles/Aging - The appearance of crow's feet, wrinkles, and signs of aging need to be diminished.

 

 

 

Skin aging is a complex process, but is mainly caused by the nonenzymatic cross-linking of skin proteins. Skin wrinkles, yellowing skin and age spots are the result of irreversible cross-linking, but their appearance on the skin can be diminished. Photoaging and dry skin contribute to the formation of surface skin wrinkles.


Face Moisturizer accelerates the recovery of the moisture barrier in aging skin by naturally restoring the moisture-holding properties of healthy, youthful skin. Alternative strategies for using Echo Moisture Stimulant™ Face Moisturizer are presented. Ari offers a money-back guarantee on Echo if not completely satisfied.

The following links load graphics into the frame at the left.

 

The Science behind BEAUTY CLASSICS®Check1red.png DermAge Moisture Invigorator™

bullet2.pngSkin lipids are produced during a process called lipogenesis. Lipogenesis is stimulated when a signal molecule, called a ligand, binds to a cell receptor located on the surface of cells, such as adipocytes (fat cells) and keratinocytes (skin cells). Ligand binding signals cells to make lipids, such as fatty acids, cholesterol and ceramides, that are eventually delivered to the protective barrier of the skin, called the stratum corneum.

bullet2.pngThe stratum corneum of the skin contains lipid lamellae sheets, which constitute the epidermal water barrier that prevents moisture loss. When cells synthesize lipids, the lipids are packaged into small organelles, called lamellar bodies. Lamellar bodies discharge their lipid content as lipid disks into the extracellular matrix. The lipid disks then fuse with the stratum corneum, replenishing it with moisture-holding lipids.

bullet2.pngAs the skin ages, not only do the number of lamellar bodies produced decrease, but there is also a decrease in the amount of lipid they contain and release as lipid disks. As a result of this lipid deficiency, there is a change in the normal structure of the stratum corneum. This structural change impairs both stratum corneum integrity and its ability to repair itself after exposure to detergents, air pollution, cosmetics, etc., which leads to moisture loss, dry skin, and surface wrinkles.

Check1red.pngDermAge Moisture Invigorator™ Face Moisturizer

bullet2.pngAs skin ages it produces less moisture-holding lipids. As a result lipid-deficient skin loses moisture and forms surface wrinkles. Dry skin also loses its ability to repair itself, leaving skin vulnerable to environmental elements that damage it. Dry skin can promote skin breakdown from shear and frictional injuries, and compromise the body's first line of defense against infection.

bullet2.pngA solution to the problem of keeping aging skin moisturized is to mimic the natural conditions in skin that stimulate lipid production.

bullet2.png DermAge Moisture Invigorator™ Face Moisturizer is the basis of BEAUTY CLASSICS® exclusive rehabilitative treatment that natural revitalizes dry, aging skin with the moisture-holding lipids of healthy, youthful skin.

bullet2.pngDermAge Moisture Invigorator™ produces lipids deep within the skin, where they are needed to fuse with the stratum corneum. Other skin care products relying on passive or inefficient delivery systems, such as diffusion with topically applied lipids or liposomes that disrupt the integrity of the stratum corneum.

bullet2.pngBy inducing the skin to produce its own lipids, the use of exogenous lipids is avoided. This is important since commercial lipids used in other brands of skin care products are often contaminated by lipid peroxides which damage skin.

bullet2.png DermAge Moisture Invigorator™ Face Moisturizer’s active ingredients are natural constituents of human skin that revitalize dry, aging skin with moisture-holding lipids.

bullet2.pngIn summary, as skin ages there is a decrease in the amount of moisture-holding lipids the skin produces. As a result, skin loses its ability to repair the stratum corneum, causing lipid-deficient aging skin to lose moisture and form wrinkles.


 

BEAUTY CLASSICS® Check1red.pngDermAge Moisture Invigorator™ Face Moisturizer Usage Strategies

bullet2.png DermAge Moisture Invigorator™ Face Moisturizer is used for dry skin or when normal skin needs a moisture lift.

bullet2.png DermAge Moisture Invigorator™ Face Moisturizer can be used as a primary face moisturizer, twice daily, morning and evening, or when skin needs additional moisture.

bullet2.pngFor those exposed to the sun, DermAge Moisture Invigorator™ Face Moisturizer can be used together with DermAge Anti-PhotoAging Defender™  Face Moisturizer to maximize the antiaging benefits of both products. Echo should be applied 10 minutes before Reflect is applied.

bullet2.png DermAge Moisture Invigorator™ Face Moisturizer can also be used as a day treatment with either DermAge AntiAging Inhibitor™ Face Moisturizer or DermAge AntiWrinkle Sculpturer™ Face Moisturizer as a night treatment.

bullet2.pngAll DermAge Skin Care Products are fragrance-free and silicone-free. DermAge Moisture Invigorator™ Face Moisturizer should be applied evenly to clean, dry skin. A temporary tingling sensation may be felt, as DermAge Moisture Invigorator™ Face Moisturizer revitalizes the skin. For sensitive skin, wait 15 minutes after cleansing face before applying. DermAge Moisture Invigorator™   Face Moisturizer should be used twice daily, morning and evening. An improvement in the appearance of the skin should be seen with daily use.

Face Moisturizer goes beyond ordinary sunscreens by restoring the natural balance in skin disturbed by exposure to UV radiation. Skin balance is restored by inhibiting oxygen radicals that causes skin sagging and wrinkling of the skin.  

bullet2.pngThe skin covers the surface of the body and therefore it undergoes a number of environmental damages, from temperature, humidity, and solar radiation. Changes in the skin that are perceived as aging are not simply a result of chronological aging, but also reflect the consequences of excessive ultraviolet (UV) exposure from sunlight.

bullet2.pngPhotoaging is the premature aging of the skin, characterized by surface wrinkles, altered pigmentation, and loss of skin tone. Until recently the mechanisms responsible for damaging the extracellular matrix of skin were unknown, but recent research has illuminated the causes of photoaging.

bullet2.pngResearch has revealed that advanced glycosylation end-products (AGEs), that are formed from a series of spontaneous chemical reactions in the skin, are in a large part responsible for the Photoaging of skin. The early stage of these spontaneous reactions is initiated by a condensation reaction between either reducing sugars, such as glucose, or oxidative products of ascorbic acid (vitamin C), such as L-threose, and the free amino groups of proteins, such as collagen and elastin.

bullet2.pngOnce glucose or L-threose are chemically attached to the protein through an amino bond, they form a Schiff base which then rearrange to form Amadori products. In the advanced stage of the reaction, the Amadori products degrade into compounds, called advanced glycosylation end-products (AGEs), which can cross-linking other protein molecules.

bullet2.pngAGEs are yellowish brown chromophores with ultraviolet A (UVA) sensitizing activity, which means they are capable of absorbing the energy in the UVA radiation and transferring it onto ground-state oxygen to form high-energy singlet oxygen radicals.

bullet2.pngThe UVA photogenerated singlet oxygen radicals cause skin damage by disrupting the natural balance in skin by stimulating skin cells to synthesize metalloproteinases, which are enzymes that degrade collagen and elastin, without countering metalloproteinases with the synthesis of anti-metalloproteinases that holds skin protein degradation in check, which is the normal biological response.

bullet2.pngThe unbalanced synthesis of metalloproteinases and anti-metalloproteinases caused by singlet oxygen radicals, leads to the breakdown of the extracellular matrix of skin. Because of the imperfect wound repair of the damaged collagenous matrix and the accumulation of elastotic material, known as solar elastosis or solar scar, the skin above eventually sags and wrinkles after chronic UV exposure.

bullet2.pngRecent research has shown that AGEs exposured to UVA radiation also causes the photolytic oxidation, i.e., the chemical decomposition by irradiation, of extracellular matrix proteins, which is mediated by the generation of reactive oxygen species.

bullet2.pngFirst, UV light enhances the generation of superoxide anions via UVA-AGE induced electron transfer. This is accomplished through the cellular electron-transport chain in which UVA-AGE energy enhances the passing of electrons onto ground state oxygen, which increases the generation of superoxide anions during the biosynthesis of adenosine triphosphate (ATP), the molecule that the body uses as an energy source.

bullet2.pngNext, superoxide anions are dismutated to hydrogen peroxide and oxygen by an enzyme, called superoxide dismutase. Finally, hydrogen peroxide is then converted to hydroxyl radicals in reactions catalyzed by iron and copper. Hydroxyl radicals cause tissue damage to the extracellular matrix of the skin by degrading collagen and elastin, which leads to imperfect wound healing and solar scar that photoages skin.

bullet2.pngSeveral studies have shown that UV radiation increases the formation of AGEs on collagen, elastin, and other skin proteins. This situation can accelerate the aging of skin by creating a vicious cycle in which UV radiation accelerates the accumulation of AGEs in skin, which in turn increases the potential for greater UVA-AGE photosensitizing activity. Increased UVA-AGE photosensitizing activity results in increased singlet oxygen and superoxide anion generation, which causes protein damage that ages skin, and so on.

bullet2.pngSunbathing causes photoaging of the skin, but most sun-induced skin damage that occurs over a person's life-time is the result of normal daily activities, which exposes skin to ultraviolet radiation, such as working outdoors or sitting near a window. Therefore, it is important to protect the skin from sun exposure at all times by using Skincare products with at least an SPF 15 value sunscreen ingredient such as the Check1red.pngBEAUTY CLASSICS™ High Quality Pharmacist Formulary Clear Skin Care and Sunscreen Products such as the SunSkinPlex™ or the DermAge™ sub-brands.

bullet2.pngUltraviolet (UV) radiation photogenerates oxygen radicals in skin that damage collagen and elastin, causing skin to wrinkle and sag. A solution to the problem of photoaging is to mimic the natural conditions in skin that inhibit UV-mediated skin damage.

bullet2.png DermAge Anti-PhotoAging Defender™ Face Moisturizer is the basis of DermAge™ exclusive preventative treatment that goes beyond mere sunscreens by quenching oxygen radicals that cause skin wrinkling and sagging. DermAge Anti-PhotoAging Defender™  inhibits skin photoaging and naturally sustains the skin’s healthy, youthful appearance. It restores the natural balance in skin disrupted by exposure to UV radiation.

bullet2.png DermAge Anti-PhotoAging Defender™ active ingredients are natural constituents of human skin that inhibit photoaging. Reflect also contains SPF 15 UVA (Parsol® 1789; Avobenzone) and UVB sunscreens that protect skin against sunburn.

bullet2.pngIn summary, UVA radiation photogenerates singlet oxygen and superoxide radicals that disrupt the normal balances in the skin, causing skin to sag and wrinkle. Therefore, it is important to protect the skin from sun exposure at all times.


 

BEAUTY CLASSICS® Dermage™ Sun Care and Alternative Use Strategies

bullet2.png DermAge Anti-PhotoAging Defender™ Face Moisturizer is used to protect skin from sun exposure that causes skin damage and photoaging.

bullet2.png DermAge Anti-PhotoAging Defender™ Face Moisturizer can be used in conjunction with other Dermage™ Skin Care Products.

bullet2.png DermAge Anti-PhotoAging Defender™ Face Moisturizer may be used as a day treatment with DermAge Anti-Aging Inhibitor™ Face Moisturizer or Dermage Anti-Wrinkle Sculpterer™ Face Moisturizer used as a night treatment.

bullet2.png DermAge Anti-PhotoAging Defender™ Face Moisturizer can also be used together with DermAge Anti-Aging Inhibitor™ Face Moisturizer or Dermage Anti-Wrinkle Sculpterer™ Face Moisturizer to maximize the anti-aging benefits of both products.The Inhibitor or Sculturer should be applied 10 minutes before the Defender is applied.

bullet2.pngAll bullet2.png DermAge™  Skin Care Products are fragrance-free and silicone-free. In addition Reflect AntiPhotoAging Protectant™ Face Moisturizer is also PABA-free. DermAge Anti-PhotoAging Defender™ Face Moisturizer should be applied evenly to clean, dry skin. A temporary tingling sensation may be felt, as DermAge Anti-PhotoAging Defender™ Face Moisturizer revitalizes the skin. For sensitive skin, wait 15 minutes after cleansing face before applying. DermAge Anti-PhotoAging Defender™ Face Moisturizer protects the skin from UV radiation for six hours. Besides inhibiting the photoaging of skin, an improvement in the appearance of the skin should also be seen with daily use.  

The Science Behind Check1red.pngDermage Anti-Wrinkle Sculpterer™   

bullet2.pngThe glycation or chemical attachment of glucose and ascorbic acid (vitamin C; ASA) to long-lived proteins, such as collagen and elastin can lead to the spontaneous formation of advanced glycosylation end-products (AGEs), which are highly reactive in cross-linking protein. Protein cross-linking is important, since it is an irreversible process that is responsible for the permanent, deep wrinkling in the dermis of the skin.

bullet2.pngOne of the sobering facts derived from the accumulated knowledge about the nonenzymatic glycation of protein is the ability of AGE-modified collagen to continue trapping and cross-linking unmodified protein, even in the absence of free glucose or ASA. This means that skin can continues to age once AGEs are formed on collagen.

bullet2.pngThe level of AGEs in collagen are low up until about the age of 18 years old, and then rapidly increases after this age. This is because there is extensively collagen remodelling occuring at younger ages, which quickly slows after maturity. The age-related increase in collagen AGE-levels correlates with accelerated skin aging and the formation of wrinkles.

bullet2.pngAlso, the values of serum AGEs for women beyond age 50 are significantly higher than for younger women. The AGE-values for women aged 80-93 is three-fold higher than women aged 20-29. There are higher AGE-values for older women, because AGE synthesis increases with age. The age-related increase in serum AGE-values correlates with accelerated skin aging and the formation of wrinkles.

bullet2.pngAlthough collagen turnover may be regulated independently from cross-linking, cross-linking itself can impair collagen turnover. This is because cross-linked collagen is less susceptible to natural corrective actions, such as collagenase digestion and macrophage-mediated degradation. Eventually, the extracellular matrix of the skin become so knotted by cross-linked collagen, that the natural balance is disturbed between the cross-linking of collagen and the mechanisms that correct collagen cross-linking.

bullet2.pngAs a result of this self-perpetuating component of glucose- and ASA-mediated tissue damage, a vicious cycle occurs in which cross-linking continues to happen with the natural remodeling process unable to correct it, further impairing collagen turnover and leading to an accelerated rate of skin aging, as seen in older people.

bullet2.pngA recent study showed that protein turnover is a major determinant in the accumulation of AGEs in skin collagen. AGEs were found to increase with age in both skin collagen and cartilage. However, AGE accumulation was higher in cartilage than in skin collagen indicating that cartilage has a slower turnover rate. Cartilage collagen was found to age more quickly than skin collagen, indicating that the remodeling of AGE-modified collagen inhibits skin aging.

 

BEAUTY CLASSICS® Check1red.pngDermage Anti-Wrinkle Sculpterer™ Face Moisturizer

bullet2.pngDuring middle-age skin aging accelerates due to increased collagen cross-linking that suppresses collagen turnover. A solution to the problem of revitalizing aging skin is to mimic the natural conditions in skin that induce skin renewal.

bullet2.png Dermage Anti-Wrinkle Sculpturer™ Face Moisturizer is the basis of DermAge’s exclusive rehabilitative treatment for mid-life adults. The Sculpturer diminishes the appearance of wrinkles and naturally revives the skin’s healthy, youthful appearance.

bullet2.png The Sculpturer active ingredients are natural constituents of human skin that rehabilitate aging skin.

bullet2.pngFor younger adults, DermAge Anti-Aging Inhibitor™ Face Moisturizer is recommended. Individuals in their thirties may benefit most by using Dermage Anti-Wrinkle Sculpterer™ Face Moisturizer as a night treatment with DermAge Anti-Aging Inhibitor™ Face Moisturizer as a day treatment.

bullet2.pngIn summary, once collagen is glycated it has the potential to form AGEs and cross-link other protein molecules. Once proteins are cross-linked, the cross-linking is irreversible. Extensive glycation and cross-linking of collagen impedes the natural remodeling mechanisms that correct cross-linking, which eventually impairs collagen turnover. This situation results in a vicious cycle in which skin aging is accelerated.


bullet2.png Dermage Anti-Wrinkle Sculpterer™ Face Moisturizer is used in cases of wrinkled skin, in order to diminishes the appearance of wrinkles and inhibit the formation of new wrinkles.

bullet2.pngYounger adults (17-29 years old) are encouraged to using DermAge Anti-Aging Inhibitor™ Face Moisturizer instead of the Sculturer as a preventative strategy to inhibit skin aging.

bullet2.png Dermage Anti-Wrinkle Sculpterer™ Face Moisturizer can be used in conjunction with other DermAge™ Skin Care Products.

  

 

 

 

 

 

 

BEAUTY CLASSICS Anti-Aging Anti-Wrinkle Advisor 60 +


Please check on your skin care concern:

bullet2.pngDry Skin - Dry skin wrinkles are conspicuously present on the face.
bullet2.pngPhotoaging - Surface and deep skin wrinkles are signs of chronic sun exposure that require attention.
bullet2.pngWrinkles/Aging - The appearance of wrinkles and and age spots needs to be diminished.

 

 

 

At 60 plus years, though skin aging can still be inhibited, results will be less satisfactory. This is because of the extent of skin damage that has occurred by 60. Photoaging is a concern at all ages. Dry skin can still be addressed most satisfactorily at 60.

 


  

 

 

 

BEAYTY CLASSICS® Check1red.pngDermAge Moisture Invigorator™ Face Moisturizer

 

As the skin ages, there is a decrease in the amount of lipids produced in the skin, which impairs both its integrity and ability to repair itself. At 60+ DermAge Moisture Invigorator™ Face Moisturizer works excellently to accelerate the recovery of the skin's moisture barrier by naturally restoring the moisture-holding properties of healthy, youthful skin.


 


 

bullet2.png DermAge Moisture Invigorator™ Face Moisturizer is used for dry skin or when normal skin needs a moisture lift.

bullet2.png DermAge Moisture Invigorator™ Face Moisturizer can used as a primary face moisturizer, twice daily, morning and evening, or when skin needs additional moisture.

bullet2.pngFor those exposed to the sun, DermAge Moisture Invigorator™ Face Moisturizer can be used together with Reflect DermAge Anti-PhotoAging Defender™ Face Moisturizer to maximize the antiaging benefits of both products. Echo should be applied 10 minutes before Reflect is applied.

bullet2.png DermAge Moisture Invigorator™ Face Moisturizer can also be used as a day treatment with either DermAge Anti-Aging Inhibitor™ Face Moisturizer or DermAge AntiWrinkle Sculpturer™ Face Moisturizer as a night treatment.

http://www.arisc.com/pt_gold13x10.gifAll DermAge™ Skin Care Products are fragrance-free and silicone-free. DermAge Moisture Invigorator™ Face Moisturizer should be applied evenly to clean, dry skin. A temporary tingling sensation may be felt, as DermAge Moisture Invigorator™ Face Moisturizer revitalizes the skin. For sensitive skin, wait 15 minutes after cleansing face before applying. DermAge Moisture Invigorator™ Face Moisturizer should be used twice daily, morning and evening. An improvement in the appearance of the skin should be seen with daily use.

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